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ATM Inhibitor-1

SKU: orb1710372

Description

ATM Inhibitor-1 is a potent, selective, and orally bioavailable small molecule inhibitor of ATM kinase with an IC50 of 0.7 nM. It demonstrates significant anti-tumor activity in preclinical models and exhibits high selectivity over related kinases like mTOR, DNA-PK, and PI3K isoforms. This compound is a valuable chemical probe for investigating DNA damage response pathways in cancer research, both in vitro and in vivo.

Research Area

Molecular Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2135639-94-8
MW492.61
FormulaC27H36N6O3
SMILESN([C@@H](C)C1CCOCC1)C=2C3=C(N=NC2C(NC)=O)C=CC(=C3)C=4C=CC(OCCCN(C)C)=NC4
TargetATM/ATR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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ATM Inhibitor-1 (orb1710372)

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