ATM Inhibitor-1

SKU: orb1710372

Description

ATM Inhibitor-1 is a potent, selective, and orally bioavailable small molecule inhibitor of ATM kinase with an IC50 of 0.7 nM. It demonstrates significant anti-tumor activity in preclinical models and exhibits high selectivity over related kinases like mTOR, DNA-PK, and PI3K isoforms. This compound is a valuable chemical probe for investigating DNA damage response pathways in cancer research, both in vitro and in vivo.

Research Area

Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2135639-94-8
• MW: 492.61
• Formula: C₂₇H₃₆N₆O₃
• SMILES: N([C@@H](C)C1CCOCC1)C=2C3=C(N=NC2C(NC)=O)C=CC(=C3)C=4C=CC(OCCCN(C)C)=NC4
• Target: ATM/ATR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

130453737