Atipamezole

SKU: orb1685616

Description

Atipamezole is a selective α2-adrenoceptor antagonist. It is utilized in research to reverse α2-agonist sedation and has been investigated in preclinical models for its potential neuroprotective and anti-Parkinsonian effects in both in vitro and in vivo studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 104054-27-5
• MW: 212.29
• Purity: 99.88%
• Formula: C₁₄H₁₆N₂
• SMILES: C(C)C1(CC=2C(C1)=CC=CC2)C3=CN=CN3
• Target: Adrenergic Receptor
• Solubility: DMSO:39 mg/mL (183.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.42 mM);Ethanol:39 mg/mL (183.71 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  α2-adrenoceptor antagonist:1.6 nM（Ki）
• In Vivo:
  Atipamezole is well-tolerated in rodents and exhibits modest cardiovascular effects (0.01–1 mg/kg, i.v.) in anesthetized, normotensive rats. It is frequently used by veterinarians to reverse sedation or anesthesia in animals. Atipamezole enhances sexual activity in rats and monkeys and increases pain-related responses in animals with sustained nociception by blocking noradrenergic feedback inhibition of pain. At low doses, it improves alertness, selective attention, planning, learning, and recall in experimental animals, although not necessarily affecting short-term working memory.
• In Vitro:
  The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Receptor, Adrenergic Receptor, AdrenergicReceptor, Atipamezole, Antisedan, Inhibitor, inhibit, MPV 1248, MPV-1248, MPV1248, α2-adrenoceptor

Compound Identifiers

PubChem CID

71310