ATIC-IN-1 acetate

SKU: orb1944638

Description

ATIC-IN-1 acetate is a small molecule inhibitor that targets the ATIC enzyme by preventing its dimerization, thereby blocking its AICAR transformylase activity. This mechanism confers potential anti-tumor properties, making it a useful tool for investigating purine biosynthesis in cancer research, both in vitro and in vivo.

Research Area

Metabolism Research

Key Properties

• MW: 523.59
• Purity: 99.74% (May vary between batches)
• Formula: C₂₃H₃₇N₇O₇
• SMILES: O=[N+](C1=CC=C(C[C@H](NC([C@H](CCCNC(N)=N)NC(C)=O)=O)C(N(CC)CC)=O)C=C1)[O-].CC(O)=O
• Target: Endogenous Metabolite,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (3.82 mM);DMSO:40 mg/mL (76.4 mM);H2O:40 mg/mL (76.4 mM)

Bioactivity

• Target IC50:
  aminoimidazolecarboxamide ribonucleotide translocase/inosine monophosphate cyclization hydrolase (ATIC):685 nM （Ki）
• In Vitro:
  ATIC-IN-1 acetate (Compound 14) is an inhibitor of aminoimidazolecarboxamide ribonucleotide translocase/inosine monophosphate cyclization hydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC-IN-1 acetate (100-500 μM, treated for 48 hours) was able to hinder the proliferation of MCF-7 cells. ATIC-IN-1 acetate (250 μM, 24-72 hours of action) decreases cell division rather than increasing cell death.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171326037