ATG7-IN-1

SKU: orb1691116

Description

ATG7-IN-1 is a potent and selective small molecule inhibitor of ATG7, exhibiting an IC50 value of 62 nM. This compound is a valuable research tool for investigating autophagy mechanisms in both cellular and animal models, aiding in the study of cancer, neurodegenerative diseases, and metabolic disorders.

Research Area

Cell Biology

Key Properties

• CAS Number: 2226229-87-2
• MW: 470.5
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₁₉FN₆O₅S₂
• SMILES: S(C=1C=2C(N(N1)[C@@H]3O[C@@H](COS(N)(=O)=O)[C@@H](O)C3)=NC=NC2N)C4=C(F)C=C(C)C=C4
• Target: Autophagy,ATG
• Solubility: DMSO:255 mg/mL (541.98 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.63 mM)

Bioactivity

• Target IC50:
  SKOV3 cells:3 μM (EC50)|NCI-H1650 cells:> 50 μM (EC50)|ATG7:62 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATG7 IN 1, ATG7IN1, ATG-7-IN-1, ATG7-IN-1, ATG7

Compound Identifiers

PubChem CID

134500786