Atg4B-IN-2

SKU: orb1689068

Description

Atg4B-IN-2 is a potent and selective autophagy-related 4B (Atg4B) and phospholipase A2 (PLA2) inhibitor. It demonstrates anticancer activity and has been investigated in vitro for its role in modulating autophagy to overcome resistance in prostate cancer models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 2765008-88-4
• MW: 330.46
• Purity: 99.65% (May vary between batches)
• Formula: C₂₁H₃₀O₃
• SMILES: C(/C=C/C(O)=O)(=O)C1=CC=C(CCCCCCCCCCC)C=C1
• Target: Autophagy,ATG,Cysteine Protease,Phospholipase
• Solubility: DMSO:80 mg/mL (242.09 mM)

Bioactivity

• Target IC50:
  Atg4B:3.1 μM (Ki)|Atg4B:11 μM|PLA2:3.5 μM
• In Vitro:
  In a dose-dependent manner, Atg4B-IN-2 (compound 21f) (1-10 μM; 2 hours) restores p62 expression in cells treated with amino acid-free (AF) conditions . At concentrations of 1 and 5 μM (2 hours), Atg4B-IN-2 moderately decreases autophagic vesicles at 1 μM and almost completely inhibits autophagy at 5 μM . At a concentration of 5 μM (2 hours), Atg4B-IN-2 inhibits Abi-induced autophagy, significantly enhances apoptotic cell death, and increases sensitivity to Abi .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PLA2, ATG4B, Autophagy

Compound Identifiers

PubChem CID

163322260