ASX-173

SKU: orb3136213

Description

ASX-173 is an orally active asparagine synthetase (ASNS) inhibitor with an IC50 of 0.113 μM and a Ki of 0.4 nM. It enhances the anticancer activity of L-Asparaginase (ASNase). When combined with ASNase, ASX-173 disrupts nucleotide synthesis and induces cell cycle arrest, apoptosis (apoptosis), and autophagy (autophagy) in leukemia cells. This combination also slows the growth of OCI-AML2 xenograft tumors. ASX-173 is applicable in research on acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2748800-08-8
• MW: 475.56
• Formula: C₂₈H₃₀FN₃O₃
• SMILES: C(NC(C1=CC=CC=C1)C2=CC=CC=C2)(=O)[C@@H]3N(C([C@H](CC)N)=O)C[C@H]([C@@H]3O)C4=CC=C(F)C=C4
• Target: CDK,PARP,Akt,ATG,Apoptosis,Caspase,Autophagy

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,PARP,Akt,ATG,Apoptosis,Caspase,Autophagy