ASTX295

SKU: orb3028450

Description

ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.

Research Area

Cell Biology

Key Properties

• CAS Number: 2093449-12-6
• MW: 630.531
• Formula: C₃₃H₃₄Cl₂FNO₆
• SMILES: O(C)[C@]1(N([C@@H]([C@@H](C(O)=O)C)C2=CC=C(Cl)C=C2)C(=O)C=3C1=C(F)C=C([C@@](CC)(O)C4CCOCC4)C3)C5=CC=C(Cl)C=C5
• Target: MDM-2/p53

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MDM-2/p53