Astragaloside I

SKU: orb1221731

Description

Astragaloside I is a natural product isolated from Astragalus.

Key Properties

• CAS Number: 84680-75-1
• MW: 840.99
• Purity: >98% (HPLC)
• Formula: C₄₃H₆₈O₁₆
• SMILES: C1[C@@H](C([C@H]2[C@]3(C1)[C@]1([C@@H](C[C@@H]2O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)[C@]2([C@](CC1)([C@H]([C@H](C2)O)[C@]1(C)O[C@@H](CC1)C(C)(C)O)C)C)C3)(C)C)O[C@@H]1OC[C@H]([C@@H]([C@H]1OC(=O)C)OC(=O)C)O
• Target: COX
• Solubility: DMSO : 50 mg/mL 57.53 mM;H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  Astragaloside I (10-40 μM) upregulates the express of β-catenin, Runx2, BGP and OPG, RANKL (osteogenesis marker genes) in MC3T3-E1 cells. Western blot analysis. Cell line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μM. Incubation time: 5 days. Result: Stimulated the expression of β-catenin and Runx2.Cell Cytotoxicity Assay. Cell line: MC3T3-E1 cells. Concentration: 0, 10, 20, 40 μM. Incubation time: 1, 3 or 6 days (The media was changed every 2 days). Result: No obvious cytotoxic effect was observed in the MC3T3-E1 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Astrasieversianin IV | Cyclosieversioside B

Quick Database Links

Gene Symbol

COX