ASP7663

SKU: orb1298958

Description

ASP7663 is a small molecule agonist of the TRPA1 ion channel. It demonstrates analgesic activity in abdominal pain models in vivo, making it a useful research tool for studying TRPA1's role in nociception and visceral pain pathways.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1190217-35-6
• MW: 263.26
• Purity: 98.61% (May vary between batches)
• Formula: C₁₄H₁₄FNO₃
• SMILES: CC(C)CN1C(=O)\C(=C\C(O)=O)c2cccc(F)c12
• Target: TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.6 mM);DMSO:11 mg/mL (41.78 mM)

Bioactivity

• In Vivo:
  ASP7663, a novel and selective TRPA1 agonist, in constipation models as well as an abdominal pain model. ASP7663 activated human, rat, and mouse TRPA1 and released 5-HT from QGP-1 cells, and oral but not intravenous administration of ASP7663 significantly improved the loperamide-induced delay in colonic transit in mice. While pretreatment with the TRPA1 antagonist HC-030031 and vagotomy both inhibited the ameliorating effect of oral ASP7663 on the colonic transit, both orally and intravenously administered ASP7663 significantly inhibited colorectal distension (CRD)-induced abdominal pain response in rats.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ASP7663, ASP-7663, ASP 7663, Inhibitor, pain, inhibit, Transient receptor potential channels, TRPA1, TRP Channel, TRPV Channel, TRPVChannel, TRPChannel

Compound Identifiers

PubChem CID

44232532