ASP3026

SKU: orb1306963

Description

ASP3026 is a small molecule inhibitor under investigation for the treatment of advanced solid tumors and lymphomas, particularly those driven by ALK or ROS1 alterations. It is utilized in preclinical research to study oncogenic signaling pathways and has demonstrated activity in both in vitro cellular assays and in vivo xenograft models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1097917-15-1
• MW: 580.74
• Purity: 99.81% (May vary between batches)
• Formula: C₂₉H₄₀N₈O₃S
• SMILES: COc1cc(ccc1Nc1ncnc(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
• Target: STAT,IGF-1R,PARP,Akt,Apoptosis,Caspase,ROS Kinase,ALK,JNK
• Solubility: DMSO:11.6 mg/mL (19.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.44 mM)

Bioactivity

• Target IC50:
  ALK:3.5 nM
• In Vivo:
  ASP3026 inhibits the growth of the NCI-H2228 human NSCLC tumor cell line, which endogenously expresses the EML4-ALK variant 3, with an IC50 value of 64.8 nM. ASP3026 demonstrates enhanced selectivity in inhibiting ALK activity in tyrosine kinases compared to PF02341066.
• In Vitro:
  Mice harboring subcutaneous NCI-H2228 tumor xenografts were treated twice daily with the oral administration of ASP3026 for 14 days, which induced a dose-dependent antitumor effect, starting at 1 mg/kg and showing a pronounced reduction at 10, 30, and 100 mg/kg.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Cluster of differentiation 246, CD246, ALK, ALK tyrosine kinase receptor, ASP 3026, ASP3026, ASP-3026, Apoptosis, Anaplastic lymphoma kinase (ALK), Anaplastic lymphoma kinase

Compound Identifiers

PubChem CID

25134326