ASM-024

SKU: orb1701165

Description

ASM-024 is a synthetic piperazine and potent nicotinic receptor agonist that induces smooth muscle relaxation via β2-adrenergic receptor signaling pathways. This compound demonstrates anti-inflammatory activity and is a research tool for investigating potential therapeutics for asthma and chronic obstructive pulmonary disease (COPD) in experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 1609534-88-4
• MW: 233.37
• Purity: 99.79% (May vary between batches)
• Formula: C₁₅H₂₅N₂
• SMILES: C(C)[N+]1(CC)CCN(CCC1)C2=CC=CC=C2
• Target: AChR
• Solubility: DMSO:2.34 mg/mL (10.03 mM)

Bioactivity

• In Vivo:
  ASM-024 increased in vitro relaxation response to maximally effective concentration of short—acting beta-2 agonists in dog and human bronchi. ASM-024 induces smooth muscle relaxation of β2-AR desensitized tracheas.
• In Vitro:
  Incubation of HBSMC cells with ASM-024 did not induce significant production of cAMP compared to salbutamol or formoterol treated cells. Fifteen minutes of incubation of hBSMC with ASM-024 alone had no effect on [Ca2+]i. However, a 10 minute pre-treatment with ASM-024 decreased [Ca2+]i rise in cells challenged with 10-6 M histamine or methacholine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ASM 024, ASM024, ASM-024, ASM-024 cation, Nicotinic Receptor

Compound Identifiers

PubChem CID

58063720