ASK1-IN-1

SKU: orb1297940

Description

ASK1-IN-1 is a potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a biochemical IC50 of 21 nM. It is a valuable research tool for investigating the role of ASK1 in cellular stress responses, apoptosis, and inflammation in both in vitro and in vivo models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2411382-24-4
• MW: 405.41
• Purity: 99.92% (May vary between batches)
• Formula: C₁₉H₁₉N₉O₂
• SMILES: COc1nn(cc1C(=O)Nc1cccc(n1)-c1nncn1C(C)C)-c1cnccn1
• Target: p38 MAPK,ASK,MAPK
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble);DMF:4 mg/mL (9.87 mM)

Bioactivity

• Target IC50:
  ASK1:138 nM(cell)|ASK1:21 nM(Biochemical)
• In Vivo:
  ASK1-IN-1 shows low clearance (rat Cl/Clu = 0.36/6.7 L h-1 kg-1) and good CNS penetration (rat K p,uu = 0.38). ASK1-IN-1 (10 mg/kg; p.o.) covers the cellular IC50/IC70/IC90 at trough in the brain for 12 hours of 50/115/435 mg/kg respectively.
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• In Vitro:
  ASK1-IN-1 shows good potency with cell IC50 of 138 nM. ASK1-IN-1 has superior CYP inhibition profile.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CNS, brain, ASK1 IN 1, ASK1, ASK1IN1, ASK-1-IN-1, ASK1-IN-1, Inhibitor, MAPK, inhibit, p38 MAPK, penetrant

Compound Identifiers

PubChem CID

146027049