AS601245.2TFA (345987-15-7 free base)

SKU: orb1685366

Description

AS601245.2TFA (345987-15-7 free base) is a potent, cell-permeable inhibitor of JNK isoforms, with IC50 values of 150 nM (hJNK1), 220 nM (hJNK2), and 70 nM (hJNK3). This compound is widely used in research to investigate JNK signaling pathways in cellular models of apoptosis, inflammation, and neurological disorders.

Research Area

Signal Transduction

Key Properties

• CAS Number: 345987-16-8
• MW: 600.50
• Formula: C₂₄H₁₈F₆N₆O₄S
• SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
• Target: JNK
• Solubility: DMSO:60 mg/mL (99.92 mM)

Bioactivity

• Target IC50:
  JNK2 (human):220 nM|JNK1 (human):150 nM|JNK3 (human):70 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNK, AS601245.2TFA, AS601245.2TFA (345987 15 7 free base), AS601245.2TFA (345987157 free base), AS-601245.2TFA (345987-15-7 free base), 345987-15-7, 345987-15-7 free base

Compound Identifiers

PubChem CID

155291125