AS2795440

SKU: orb3136949

Description

AS2795440 is a PIKfyve inhibitor. It selectively suppresses the production of pro-inflammatory cytokines such as IL-12p40 and IL-6 and the activation of B cells, without affecting Ca2+ signaling. In a mouse model of adjuvant-induced arthritis (AIA), AS2795440 significantly reduces joint inflammation and bone loss. This compound is useful for researching inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2171506-45-7
• MW: 480.60
• Formula: C₂₉H₃₂N₆O
• SMILES: O=C(NC=1C=C(C=NC1C)C=2C=NC(=CC2)C3=CCN(CC3)C(C)C)C4=NC5=C(C=C4)NC(=C5C)C
• Target: PI3K,Interleukin,MHC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,Interleukin,MHC