AS2677131

SKU: orb3173464

Description

AS2677131 is a potent and orally active PIKfyve inhibitor. It suppresses IL-12p40, IL-6, and IL-1β through the PIKfyve-c-Rel pathway and selectively inhibits the DNA-binding activity of c-Rel with IL-12p40 and IL-1β promoters. Additionally, AS2677131 represses the expression of MHCII molecules on B cells. This compound is applicable for research in inflammation and immunology, such as in arthritis.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2171502-44-4
• MW: 470.58
• Formula: C₂₇H₃₀N₆O₂
• SMILES: C(C)C=1C=2C(NC1C)=CC=C(C(NC=3C=C(C=NC3)C=4C=CC(=NC4)N5C[C@@H](C)O[C@@H](C)C5)=O)N2
• Target: PI3K,Interleukin,MHC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,Interleukin,MHC