AS-1949490

SKU: orb1308636

Description

AS1949490 is a potent and selective SHIP2 inhibitor (IC50=620 nM) that enhances glucose metabolism in L6 myotubes by upregulating GLUT1 expression. This compound is a valuable research tool for studying insulin signaling and metabolic disorders in cellular models.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 1203680-76-5
• MW: 371.9
• Purity: >98%
• Formula: C₂₀H₁₈ClNO₂S
• SMILES: C[C@H](NC(=O)c1sccc1OCc1ccc(Cl)cc1)c1ccccc1
• Target: Phosphatase
• Solubility: Soluble in DMSO (up to at least 40 mg/ml)

Bioactivity

• Target IC50:
  SHIP2:620 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SHP-2, Phosphatase, SHIP-2, Protein kinase B, PKB, diabetes, Akt, AS 1949490, AS1949490, AS-1949490, L6 myotubes, insulin signalling pathway, Inhibitor, glucose uptake, glucose consumption, inhibit

Compound Identifiers

PubChem CID

44473434