AS1940477

SKU: orb1741159

Description

AS1940477 is a potent and selective p38α/β MAPK inhibitor. It effectively suppresses proinflammatory cytokine production in cellular assays (e.g., PBMCs, synovial cells) and demonstrates significant oral anti-inflammatory efficacy in vivo, including in LPS-challenged rat models. This inhibitor is a valuable tool for researching p38 MAPK signaling in inflammation and related diseases.

Key Properties

• CAS Number: 928344-12-1
• MW: 431.46
• Formula: C₂₄H₂₂FN₅O₂
• SMILES: C(O)[C@H]1CN2C(=C(C(=N2)C3=CC=C(F)C=C3)C4=NN(C(=O)C=C4)C5=C(C)C=CC=C5)NC1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

136173253