AS1810722

SKU: orb1217490

Description

AS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.

Key Properties

• CAS Number: 909561-15-5
• MW: 477.52
• Purity: >98% (HPLC)
• Formula: C₂₅H₂₅F₂N₇O
• SMILES: O=C(N)CN1CCN(C2=CC=C(NC3=NC=C4C(N(CC5=CC(F)=CC(F)=C5)C=C4)=N3)C=C2)CC1
• Target: P450
• Solubility: DMSO : 62.5 mg/mL (130.89 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Female Balb/c mice asthmatic model by intraperitoneal injection of ovalbumin (OVA)-containing aluminum hydroxide gel. Dosage: 0.03-0.3 mg/kg. Administration: Orally; 30 min before, and 24 and 48 h after OVA exposure. Result: Suppressed eosinophil infiltration in the lung in a dose-dependent manner.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P450