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AS1604498

SKU: orb3211424

Description

AS1604498 is a highly specific, competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. It functionally suppresses NAMPT enzyme activity, reducing the production of nicotinamide mononucleotide and decreasing intracellular NAD levels, which activates caspase 3/7 and induces apoptosis in cancer cells. AS1604498 can be utilized in research related to chronic myeloid leukemia.

Images & Validation

Key Properties

CAS Number361465-74-9
MW319.36
FormulaC19H17N3O2
SMILESO=C(NCCCN1C=NC=C1)C=2OC(C#CC=3C=CC=CC3)=CC2
TargetApoptosis,Caspase,NAMPT

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information