AS1269574

SKU: orb1306270

Description

AS1269574 is a potent and orally bioavailable agonist of the GPR119 receptor. It is a research compound for investigating type 2 diabetes, with studies demonstrating its potential to stimulate insulin secretion in vitro and improve glucose tolerance in animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 330981-72-1
• MW: 308.17
• Purity: 99.99% (May vary between batches)
• Formula: C₁₃H₁₄BrN₃O
• SMILES: Cc1cc(NCCO)nc(n1)-c1ccc(Br)cc1
• Target: GPCR,TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.22 mM);DMSO:250 mg/mL (811.24 mM)

Bioactivity

• In Vivo:
  In in vivo studies, a single administration of AS1269574 to normal mice reduced blood glucose levels after oral glucose loading based on the observed insulin secretion profiles. Significantly, AS1269574 did not affect fed and fasting plasma glucose levels in normal mice. AS1269574 represents a novel structural class of small molecule, orally administrable GPR119 agonists with GSIS and promising potential for the treatment of type 2 diabetes.
• In Vitro:
  AS1269574 had an EC(50) value of 2.5μM in HEK293 cells transiently expressing human GPR119 and enhanced insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions. This contrasted with the action of the sulfonylurea glibenclamide, which also induced insulin secretion under low-glucose conditions (2.8mM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cation, channels, diabetes, AS 1269574, AS1269574, AS-1269574, GPR119, G Protein-Coupled Receptor 119, glucose, Inhibitor, insulin, inhibit, secretion, type, Transient receptor potential channels, TRP Channel, TRPVChannel, TRPV Channel, TRPChannel, TRPA1

Compound Identifiers

PubChem CID

5332859