AS-605240 potassium

SKU: orb3027985

Description

AS-605240 (potassium) is an orally active PI3Kγ inhibitor with an IC50 of 8 nM and a Ki of 7.8 nM. It inhibits MCP-1 and CSF1-induced PKB phosphorylation with IC50 values of 0.181 µM and 0.550 µM, respectively. In mouse models of peritonitis induced by RANTES (CCL5) and thioglycolate, AS-605240 (potassium) reduces neutrophil recruitment, showing EC50 values of 9.1 mg/kg and 10 mg/kg. Additionally, AS-605240 (potassium) ameliorates arthritis induced by αCII-IA in mice.

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Key Properties

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Formula	C₁₂H₆KN₃O₂S
Target	Akt,PI3K

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

Akt,PI3K

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