AS-0141

SKU: orb1710117

Description

AS-0141 (Cdc7-IN-6) is a highly potent and selective inhibitor of Cdc7 kinase, demonstrating an IC50 of 4 nM. It exhibits robust anti-tumor activity in cellular assays and has shown efficacy in reducing tumor growth in preclinical in vivo models, supporting its use in cancer research.

Research Area

Cell Biology

Key Properties

• CAS Number: 1402057-88-8
• MW: 465.43
• Purity: >99.99% (May vary between batches)
• Formula: C₂₁H₂₂F₃N₅O₄
• SMILES: N(C1=C(C(OCC)=O)C(=O)C(=CC=2C=3C(NC2)=NC=CC3)O1)N4CCN(CC(F)(F)F)CC4
• Target: CDK
• Solubility: DMSO:76.5 mg/mL (164.36 mM)

Bioactivity

• In Vitro:
  AS-0141 demonstrates potent inhibitory activity (IC50<3 µΜ) across a variety of solid tumor cell lines, including sarcoma (143B, CADO-ES1, RD-ES, A673), bladder (5673, RT1 12/84), colon and cecum (Colo-205, DLD-1, LS1034, SK-CO-1, SNU-C1), renal (U0.31), melanoma (A2058, A875), head-and-neck (CNE-2Z, RPMI-2650), and gastric (HGC-27) lineages.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cdc7-IN-6, Cdc7, AS 0141, AS0141, AS-0141, SRA 141, SRA141, SRA-141, PNT 141, PNT141, PNT-141

Compound Identifiers

PubChem CID

136338211