Arvanil

SKU: orb1704676

Description

Arvanil is a synthetic hybrid molecule acting as a dual ligand for the vanilloid VR1 and cannabinoid CB1 receptors. It demonstrates neuroprotective and antispasmodic properties and has been shown in research to induce ferroptosis in hepatocellular carcinoma cells, both in vitro and in vivo, by targeting MICU1, thereby enhancing chemosensitivity.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 128007-31-8
• MW: 439.63
• Purity: >99.99% (May vary between batches)
• Formula: C₂₈H₄₁NO₃
• SMILES: C(NC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC(OC)=C(O)C=C1
• Target: TRP/TRPV Channel,Cannabinoid Receptor
• Solubility: Ethanol:8 mg/mL (18.2 mM)

Bioactivity

• In Vivo:
  Arvanil (2 mg/kg, intrabitoneally injected) induced anti-hyperkinetic state in rats injected with 3-nitropropionic acid (3-NP) in bilateral striatum.
• In Vitro:
  Arvanil directly binds to two amino acid sites of mitochondrial calcium uptake protein 1 (MICU1), Ser47 and Phe128, triggering iron death in living cells. Arvanil inhibits lymphocyte proliferation and IFN-γ production. Phenotypes of activated CD4+T cells treated with Arvanil showed downregulation of T cell activation markers such as CD25, HLA-DR, and CD134/OX40.

Storage & Handling

• Storage: store at low temperature,High Volatility | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-Vanillylarachidonamide, Arvanil

Compound Identifiers

PubChem CID

6449767