ARV-825

SKU: orb1301793

Description

ARV-825

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1818885-28-7
• MW: 923.43
• Purity: 98.00%
• Formula: C₄₆H₄₇ClN₈O₉S
• SMILES: CC=1C2=C(N3C([C@H](CC(NC4=CC=C(OCCOCCOCCOCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)C=C4)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C
• Target: PROTACs,Epigenetic Reader Domain
• Solubility: DMSO:127.5 mg/mL (138.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.17 mM)

Bioactivity

• Target IC50:
  BRD4 BD1:90 nM (Kd)|BRD4 BD2:28 nM (Kd)
• In Vitro:
  ARV-825 more effectively suppresses c-MYC levels and downstream signaling than small molecule BRD4 inhibitors resulting in more effective cell proliferation inhibition and apoptosis induction in BL.In Burkitt's lymphoma cells, ARV-825 reduces c-Myc levels, blocks cell proliferation, and induces apoptosis.
• Cell Research:
  Cells (50000/100ul) were seeded in 96-well tissue culture plates followed by addition of ARV-825 at indicated concentration. After 72 hours, 100 μL per well of reconstituted CellTiter-Glo reagent was added and read on Cytation 3 imaging reader. Relative cell growth was determined by comparing assay readings of treated cells with control DMSO treated cells. For apoptosis induction, Caspase-Glo 3/7 Assay was used following manufacturer s instruction.

Storage & Handling

• Storage: store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD4, ARV825, ARV-825, ARV 825, EpigeneticReaderDomain, Epigenetic Reader Domain, Inhibitor, inhibit, PROTACs

Compound Identifiers

PubChem CID

92044400