Artemisitene

SKU: orb1219194

Description

Artemisitene is the oxidized form of Artemisinin and is an antimalarial agent. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinin B, Artemisitene, Artemisinic acid, etc.

Key Properties

• CAS Number: 101020-89-7
• MW: 280.32
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₀O₅
• SMILES: C[C@H](CCC1C2=C)[C@H](CC3)[C@]11OO[C@@]3(C)O[C@H]1OC2=O
• Target: Others
• Solubility: DMSO:Soluble

Bioactivity

• In Vivo:
  In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage.
• In Vitro:
  Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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