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ARS-1323-alkyne

SKU: orb2665614

Description

ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number2436544-27-1
MW569
Purity99.00%
FormulaC28H27ClF2N6O3
SMILESCN(CC#C)C(=O)CCNc1nc(N2CCN(CC2)C(=O)C=C)c2cc(Cl)c(c(F)c2n1)-c1c(O)cccc1F
TargetRas,Kras
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.51 mM);DMSO:35.71 mg/mL (62.76 mM)

Storage & Handling

Storagestore at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

ARS 1323 alkyne, ARS1323alkyne, ARS-1323-alkyne, inhibit, KRAS G12C, Inhibitor, Ras

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    2436544-27-1

    569

    C28H27ClF2N6O3

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Protocol Information

ARS-1323-alkyne (orb2665614)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 220.00
5 mg
$ 510.00
10 mg
$ 830.00
25 mg
$ 1,200.00
50 mg
$ 1,610.00
100 mg
$ 2,160.00
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