ARRY 520 hydrochloride

SKU: orb1296056

Description

ARRY-520 hydrochloride is a potent and selective kinesin spindle protein (KSP/Eg5) inhibitor. It exhibits anti-proliferative activity by inducing mitotic arrest and apoptosis in cancer cells, and has been investigated in preclinical in vitro and in vivo studies for oncology research, particularly in hematological malignancies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1385020-40-5
• MW: 456.94
• Purity: 99.62% (May vary between batches)
• Formula: C₂₀H₂₃ClF₂N₄O₂S
• SMILES: O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.[H]Cl
• Target: Apoptosis,Kinesin,KSP
• Solubility: DMSO:50 mg/mL (109.42 mM)

Bioactivity

• In Vivo:
  ARRY 520 has anti-tumor activitiy in vivo. ARRY 520 induced a decrease in tumor kinetics in a dose-dependent manner in female nude mice, EOC mice xenograft model.
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• In Vitro:
  ARRY 520 causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells. ARRY 520 induces mitotic arrest in multiple cell lines and exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors.ARRY 520 induces apoptosis in a dose-dependent manner in HeLa cells. ARRY 520 potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells. ARRY 520 is able to induce caspase-2 activation. ARRY 520 is cytotoxic in Type II EOC cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KSP, ARRY 520 Hydrochloride, ARRY 520 hydrochloride, ARRY520 Hydrochloride, ARRY-520 Hydrochloride

Compound Identifiers

PubChem CID

72942033