Aromatase-IN-8

SKU: orb3175194

Description

Aromatase-IN-8 is a selective aromatase inhibitor with an IC50 of 0.05 µM for aromatase activity. It exhibits selective antiproliferative effects on estrogen receptor-positive breast cancer cell lines while being non-toxic to non-tumor cells. Aromatase-IN-8 suppresses estrogen activity, elevates testosterone levels, and downregulates estrogen receptor expression and phosphorylation. It is applicable for research in triple-negative breast cancer.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1244904-19-5
• MW: 346.88
• Formula: C₁₇H₁₉ClN₄S
• SMILES: ClC1=C(C(=NN1C)C)CN(CC=2C=NC=CC2)CC3=CSC=C3
• Target: Cytochromes P450

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cytochromes P450