ARN25068

SKU: orb1688677

Description

ARN25068 is a sub-micromolar inhibitor of GSK-3β, FYN, and DYRK1A kinases. It reduces pathological tau hyperphosphorylation, making it a useful research tool for studying neurodegenerative mechanisms in cellular and animal models of tauopathy.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2649882-80-2
• MW: 362.45
• Purity: 99.75% (May vary between batches)
• Formula: C₁₉H₁₈N₆S
• SMILES: N(C1=C2C(=NC(NCC3=CC=CC=C3)=N1)C=CS2)C=4C=C(NN4)C5CC5
• Target: Microtubule Associated,Src,GSK-3,DYRK
• Solubility: DMSO:55 mg/mL (151.75 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.8 mM)

Bioactivity

• Target IC50:
  GSK-3β:4.17 μM|FYN:2.17 μM
• In Vitro:
  ARN25068 diminishes tau phosphorylation levels in the Tau0N4R-TM-tGFP U2OS cell line.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MicrotubuleAssociated, Microtubule Associated, Fyn, GSK-3β, GSK3, DYRK1A, tau

Compound Identifiers

PubChem CID

49830886