ARN22089

SKU: orb2566952

Description

ARN22089 is an orally bioavailable small molecule inhibitor targeting the CDC42 GTPase interaction. It demonstrates in vivo efficacy by suppressing tumor growth in BRAF-mutant melanoma, as validated in mouse models and patient-derived xenografts (PDXs). This inhibitor is a valuable research tool for studying oncogenic signaling pathways in both cellular and animal studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2248691-29-2
• MW: 373.49
• Purity: 98.37%
• Formula: C₂₃H₂₇N₅
• SMILES: N=1C(=CC(=NC1C2CCNCC2)C=3C=CC=CC3)NC4=CC=CC(=C4)N(C)C
• Target: CDK,Ras

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARN 22089

Compound Identifiers

PubChem CID

142466546