ARN-21934

SKU: orb1303880

Description

ARN-21934

Research Area

Molecular Biology

Key Properties

• CAS Number: 2230854-93-8
• MW: 360.46
• Purity: 100.00% (May vary between batches)
• Formula: C₂₁H₂₄N₆
• SMILES: CN(C)c1ccc(Nc2nc(nc3CCC(N)Cc23)-c2ccncc2)cc1
• Target: Topoisomerase
• Solubility: DMSO:40 mg/mL (110.97 mM)

Bioactivity

• Target IC50:
  Topo II:2 μM
• In Vivo:
  ARN-21934 is able to reach the brain, with a maximum concentration of compound at 60 min, and is still present in the brain 360 min after injection. ARN-21934 (intraperitoneal injection; 10 mg/kg) reaches a maximal plasma concentration of 0.68 μg/mL after 15 min. The half-life and clearance value are 149 min in circulation and 0.116 L/(min kg).
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• In Vitro:
  ARN-21934 is more potent against the α isoform. ARN-21934 exhibits a small panel of human cancer cell lines such as melanoma (A375, IC50 = 12.6 μM and G-361, IC50 = 8.1 μM), breast (MCF7, IC50 = 15.8 μM), endometrial (HeLa, IC50 = 38.2 μM), lung (A549, IC50 = 17.1 μM), and androgen-independent prostate (DU145, IC50 = 11.5 μM) cancer cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARN21934, ARN-21934, ARN 21934, anticancer, DNA relaxation, Inhibitor, inhibit, topoisomerase IIα, Topo II, Topoisomerase

Compound Identifiers

PubChem CID

135150944