Arglabin

SKU: orb1296162

Description

Arglabin, a sesquiterpene lactone isolated from Artemisia glabella, acts as a selective NLRP3 inflammasome inhibitor. Its anti-inflammatory and pro-apoptotic properties support research in atherosclerosis and oncology, as demonstrated in cellular assays and animal models of disease.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 84692-91-1
• MW: 246.3
• Purity: 99.62% (May vary between batches)
• Formula: C₁₅H₁₈O₃
• SMILES: [H][C@@]12CC[C@]3(C)O[C@@]33CC=C(C)[C@]3([H])[C@@]1([H])OC(=O)C2=C
• Target: Autophagy,Transferase,NOD,NOD-like Receptor (NLR)
• Solubility: DMSO:95 mg/mL (385.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (13.4 mM)

Bioactivity

• In Vitro:
  Arglabin-stimulated macrophages displayed a strong cytotoxic activity and the lowest doses (1.25 μg/mL and 0.125 μg/mL) induced a significant stimulation of cell mitochondrial metabolism, which correlated with [3H]TdR uptake by J774.1 cells under the same experimental conditions. Arglabin triggered the production of the three cytokines from J774-1 cells . Arglabin exhibits anti exudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma . Arglabin is able to reduce the proportion of AML stem cells (CD34+CD38-) in primary AML cells .

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

proto-oncogene, RAS, (+)-Arglabin, anti-inflammatory, antitumor, Arglabin, Autophagy, NOD-like Receptor, NODlike Receptor (NLR), NODlikeReceptor, NOD-like Receptor (NLR), NODlikeReceptor(NLR), NLR, NLRP3, inhibit, inflammasome, Ftase, Farnesyl Transferase, Inhibitor

Compound Identifiers

PubChem CID

5574924