(Arg)9 TFA

SKU: orb1219873

Description

(Arg)9 TFA (Nona-L-arginine TFA), a cell-penetrating peptide, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.Poly-arginine (e.g. (Arg)9) and arginine-rich peptides (e.g. TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. (Arg)9 provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC50=0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC50=0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC50=6 μM).(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after permanent middle cerebral artery occlusion (MCAO) reduces infarct volume.

Key Properties

• CAS Number: 2283335-13-5
• MW: 1537.71
• Purity: >98% (HPLC)
• Formula: C₅₆H₁₁₁N₃₆F₃O₁₂
• SMILES: OC(=O)C(F)(F)F.N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• Target: neuroprotection
• Solubility: H2O

Bioactivity

• In Vivo:
  (Arg)9 (Nona-L-arginine; 1 μM/kg (600 μL); i. v. ; once, for 30min; male Sprague–Dawley ratspermanent middle cerebral artery stroke model) TFA shows neuroprotective effects and reduces infarct volume. Animal model: Male Sprague–Dawley rats (270 to 320 g) permanent middle cerebral artery stroke model. Dosage: 1 μM/kg (600 μL). Administration: Intravenous injection; once, over 5 minutes. Result: Reduced significantiy 20% in infarct volume.
• In Vitro:
  (Arg)9 (Nona-L-arginine; 5-10 μM) TFA provides significant neuroprotection in a dose-response manner following glutamic acid exposure (IC50 = 0.78 μM). Following kainic acid exposure, (Arg)9 TFA is neuroprotective, but less effective than in the glutamic acid model (IC50 = 0.81 μM). (Arg)9 TFA also shows neuroprotection following in vitro ischemia (IC50 = 6 μM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nona-L-arginine (TFA),Peptide R9 (TFA)

Quick Database Links

Gene Symbol

neuroprotection