Arf1-GEFs-IN-1

SKU: orb3136783

Description

Arf1-GEFs-IN-1 is a potent and orally active inhibitor of ADP-ribosylation factor 1-guanine nucleotide exchange factors (Arf1-GEFs), exhibiting an IC50 value of 40 μM in CT26 cells. Primarily, Arf1-GEFs-IN-1 induces tumor regression by triggering anti-tumor immune responses rather than direct cytotoxicity. It effectively enhances CCL5 expression and demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 is applicable in colon cancer research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3091068-95-7
• MW: 362.45
• Formula: C₁₉H₁₈N₆S
• SMILES: N(/N=C/C=1C=C2C(=CC1)NC=C2)C3=C4C5=C(SC4=NC=N3)CN(C)CC5
• Target: GTPase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GTPase