Arcyriaflavin A

SKU: orb1704942

Description

Arcyriaflavin A, a natural product isolated from Eudistoma sp., is a potent inhibitor of CDK4, CDK1, and CaMKII kinases. It also demonstrates cytotoxic activity against HCT-116 and NCI-H460 cancer cell lines. This compound is a valuable research tool for studying cell cycle regulation and kinase signaling pathways in vitro.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 118458-54-1
• MW: 325.32
• Purity: 99.64% (May vary between batches)
• Formula: C₂₀H₁₁N₃O₂
• SMILES: O=C1NC(=O)C2=C1C1=C(NC3=C1C=CC=C3)C1=C2C2=C(N1)C=CC=C2
• Target: Antifungal,Endogenous Metabolite
• Solubility: DMSO:20 mg/mL (61.48 mM)

Bioactivity

• In Vitro:
  Arcyriaflavin A has inhibitory effects on D1-CDK4, B-CDK1 and CaMKII, with IC50 values ​​of 0.14μM, 1.13μM and 0.025μM, respectively. Arcyriaflavin A has inhibitory effects on HCT-116 and NCI-H460 cells, with IC50 values ​​of 0.85μM and 0.59μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, Microbial Metabolite, Arcyriaflavin A

Compound Identifiers

PubChem CID

5327723