Arctiin

SKU: orb1305048

Description

Arctiin, also known as Arctigenin-4-glucoside, is a small molecule agonist of the adiponectin receptor 1 (AdipoR1). It has demonstrated anti-cancer properties in research, with studies indicating its activity in both in vitro cell-based assays and in vivo animal models of tumor growth.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 20362-31-6
• MW: 534.55
• Purity: 99.81% (May vary between batches)
• Formula: C₂₇H₃₄O₁₁
• SMILES: COc1ccc(C[C@H]2COC(=O)[C@@H]2Cc2ccc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(OC)c2)cc1OC
• Target: NF-κB,Adiponectin Receptor
• Solubility: Ethanol:93 mg/mL (173.98 mM);H2O:37 mg/mL (69.22 mM);DMSO:50 mg/mL (93.54 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.74 mM)

Bioactivity

• In Vivo:
  Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice.
• In Vitro:
  Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer.
• Cell Research:
  HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference)

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 315527, NSC315527, NSC-315527, Arctigenin-4-glucoside, Arctii, Arctiin, Adiponectin receptor, Adiponectinreceptor

Compound Identifiers

PubChem CID

100528