Arbutin

SKU: orb1224941

Description

Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.(In Vitro):Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner.Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM.(In Vivo):Arbutin (50 mg/kg, 100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice) pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 497-76-7
• MW: 272.25
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₆O₇
• SMILES: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(O)C=C2
• Target: Tyrosinase
• Solubility: Water: 55 mg/mL (202.02 mM); DMSO: 55 mg/mL (202.02 mM)

Bioactivity

• In Vivo:
  Animal model: Male C57BL/6 mice (20-25 g). Dosage: 50 mg/kg, 100 mg/kg. Administration: Oral administration; every day; for 17 days. Result: Ameliorated the ISO-induced myocardial injury.
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• In Vitro:
  Cell Viability Assay Cell line: B16 murine melanoma cells. Concentration: 0.3 mM, 0.7 mM, 1.4 mM, 2.1 mM, 2.9 mM, 3.6 mM, 5.4 mM Incubation time: 24 hours, 48 hours or 72 hours. Result: Inhibited the viability of B16 murine melanoma cells in a time- and dose-dependent manner. Apoptosis Analysis Cell line: B16 murine melanoma cells. Concentration: 1.4 mM, 2.9 mM, 5.4 mM Incubation time: 24 hours. Result: Caused apoptosis in 19.3% of the cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-Arbutin | NSC 4036

Quick Database Links

Gene Symbol

Tyrosinase