ARB-272572 hydrochloride

SKU: orb2276789

Description

ARB-272572 hydrochloride is a potent small-molecule inhibitor of the PD-1/PD-L1 interaction, demonstrating an IC50 of 400 pM in HTRF assays. It functions by inducing PD-L1 dimerization to block the immune checkpoint pathway, making it a valuable tool for in vitro and in vivo cancer immunology research.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2377524-19-9
• MW: 568.68(Free base）
• Purity: 99.38% (May vary between batches)
• Formula: C₃₂H₃₆N₆O₄.xClH
• SMILES: Cl.O=C(NC1=CC=CC(C=2C=CC=C(NC(=O)C3=NC=C(C=C3)CNCCO)C2C)=C1C)C4=NC=C(C=C4)CNCCO xHCl
• Target: PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PD-1, PD1, PD1/PDL1, ARB-272572 hydrochloride(2368182-63-0 Free base), ARB272572hydrochloride(2368182630Freebase), PDL1, PD-L1

Compound Identifiers

PubChem CID

139537263