AR antagonist 11

SKU: orb3028257

Description

AR antagonist 11 (Compound c2) is a selective androgen receptor antagonist with an IC50 of 0.019 μM. It is also effective against the ARF877L/T878A mutant (IC50: 1.03 μM). Additionally, AR antagonist 11 inhibits LNCaP cell proliferation and decreases PSA protein expression (IC50: 0.54 μM). This compound is applicable in prostate cancer (PCa) research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 3005979-40-5
• MW: 336.815
• Formula: C₂₀H₁₇ClN₂O
• SMILES: ClC1=CC=C([C@H]2[C@@]3([C@](C=4C=5C(C=CC4N2)=NC=CC5)(OCC3)[H])[H])C=C1
• Target: Androgen Receptor,Serine Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Androgen Receptor,Serine Protease