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AR-A014418

SKU: orb1224963

Description

A potent, specific ATP-competitive inhibitor of GSK-3β with Ki/IC50 of 38/104 nM; shows no significantly inhibition on CDK2, CDK5 (IC50>100 uM) or 26 other kinases; inhibits tau phosphorylation at a GSK3-specific site (Ser-396) in cells and protects N2A neuroblastoma cells against cell death mediated by inhibition of PI3K/Akt pathway.

Images & Validation

Key Properties

CAS Number487021-52-3
MW308.3131
Purity>98% (HPLC)
FormulaC12H12N4O4S
SMILESCOc1ccc(cc1)CNC(=O)Nc2ncc(s2)[N+](=O)[O-]
TargetGSK-3
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AR-AO 14418 | AR 0133418 | AR 014418 | GSK 3β inhibitor

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Protocol Information

AR-A014418 (orb1224963)

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Available Sizes

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500 mg
5 mg
$ 90.00
10 mg
$ 100.00
25 mg
$ 150.00
50 mg
$ 240.00
100 mg
$ 400.00
200 mg
$ 510.00