AR-9281

SKU: orb1219303

Description

AR9281 is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes.

Key Properties

• CAS Number: 913548-29-5
• MW: 319.44
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₉N₃O₂
• SMILES: CC(=O)N1CCC(CC1)NC(=O)NC23CC4CC(CC(C4)C2)C3
• Target: s-EH
• Solubility: DMSO:25 mg/mL (78.26 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  AR-9281 (APAU) (oral, 150-200 mg/dL, for 6 weeks) enhances the therapeutic effects of EETs, slows progression of hyperglycemia, protects the myocyte structure, and reduces Ca2+ dysregulation and SERCA remodeling in hyperglycemic rats. Animal model: T2DM rat model. Dosage: 150-200 mg/dL. Administration: oral(drinking), for 6 weeks. Result: Attenuated the progressive increase of blood glucose concentration and preserved mitochondrial structure and myofibril morphology in cardiac myocytes. Protected the intracellular Ca2+ effector system. Had less downregulation of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) and lowed expression of hypertrophic markers.
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• In Vitro:
  AR-9281 (APAU) has inhibitory activity for human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

APAU

Quick Database Links

Gene Symbol

s-EH