APTO-253 isomer

• Catalog Number: orb1738774
• Category: Small Molecules
• Description: APTO-253 isomer
• CAS Number: 1422826-80-9
• Purity: 0.98
• MW: 367.38
• SMILES: CC1=C(C=2NC=3C(=C4C(=C5C3C=CC=N5)N=CC=C4)N2)C=6C(N1)=CC(F)=CC6
• Formula: C₂₂H₁₄FN₅
• Biological Activity: APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.