APTO-253 isomer

SKU: orb1738774

Description

APTO-253 isomer is a 6-fluoro-substituted analog of the MTF-1 inhibitor APTO-253 (LOR-253). It functions by inhibiting MTF-1 to induce KLF4 expression, leading to cell cycle arrest via cyclin D1 downregulation. This compound is used in cancer research, with studies demonstrating its activity in both cellular and animal models of leukemia and solid tumors.

Key Properties

• CAS Number: 1422826-80-9
• MW: 367.38
• Formula: C₂₂H₁₄FN₅
• SMILES: CC1=C(C=2NC=3C(=C4C(=C5C3C=CC=N5)N=CC=C4)N2)C=6C(N1)=CC(F)=CC6
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71263684