APTO-253 HCl

• Catalog Number: orb1739207
• Category: Small Molecules
• Description: APTO-253 HCl
• CAS Number: 1691221-67-6
• Purity: 0.98
• MW: 403.84
• SMILES: Cl.Cc1[nH]c2ccc(F)cc2c1-c1nc2c([nH]1)c1cccnc1c1ncccc21
• Formula: C₂₂H₁₅ClFN₅
• Biological Activity: APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.