APS6-45

SKU: orb1298590

Description

APS6-45

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2188236-41-9
• MW: 548.39
• Purity: >99.99% (May vary between batches)
• Formula: C₂₃H₁₆F₈N₄O₃
• SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(ccc3F)C(F)(C(F)(F)F)C(F)(F)F)cc2)ccn1
• Target: Ras,MAPK
• Solubility: DMSO:240 mg/mL (437.64 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.02 mM)

Bioactivity

• In Vivo:
  APS6-45 did not affect body weight of dosed(10 mg/kg) mice after 30 d.APS6-45 (0.1-160 mg/kg; a single p.o.) does not cause detectable toxic effects in mice.
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• In Vitro:
  APS6-45 (1 μM; 1 h) strongly inhibits RAS pathway activity signaling in human MTC cell lines TT and MZ-CRC-1.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Carcinoma, antitumor, APS6 45, APS645, APS-6-45, APS6-45, calibrated, inhibit, Inhibitor, MAPK, Medullary, tumor, TCI, signaling, Ras, Thyroid

Compound Identifiers

PubChem CID

131953288