APR-246

SKU: orb1224790

Description

APR-246 (PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation; also restores the pro-apoptotic function to mutant TAp63γ and TAp73β in tumor cells but has less effect on TAp73α;induces mutant p53-dependent mitochondria-mediated apoptosis through activation of caspase-2 with subsequent cytochrome c release and further activation of downstream caspase-9 and caspase-3; inhibits tumor xenograft growth in vivo.Ovarian Cancer Phase 2 Clinical.

Key Properties

• CAS Number: 5291-32-7
• MW: 199.25
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₇NO₃
• SMILES: O=C1C(COC)(CO)N2CCC1CC2
• Target: MDM2-p53
• Solubility: DMSO: 20mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PRIMA-1MET

Quick Database Links

Gene Symbol

MDM2-p53