APL-1081 Antibody

SKU: orb2803422

Description

APL-1081 (Mal-Exo-EVC-MMAE) is a linker-payload complex for constructing antibody-drug conjugates (ADCs). It features the protease-cleavable Mal-Exo-EEVC linker conjugated to the cytotoxic agent MMAE, a potent microtubule inhibitor. This compound is utilized in ADC research for evaluating drug delivery and efficacy in both in vitro and in vivo cancer models.

Key Properties

• CAS Number: 2921735-80-8
• MW: 1502.79
• Formula: C₇₅H₁₁₅N₁₃O₁₉
• SMILES: [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OC(C(NCCCCCN3C(=O)C=CC3=O)=O)C4=CC=C(NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC(C)=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C4)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Target: Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172898554