Apigenin-7-glucuronide

SKU: orb1301309

Description

Apigenin-7-glucuronide is a bioactive flavonoid metabolite with demonstrated antioxidant, anti-inflammatory, and aldose reductase inhibitory properties. It potently inhibits several matrix metalloproteinases (MMPs), particularly MMP-13 (IC50 = 0.27 µM), supporting its research relevance in inflammation, fibrosis, and diabetic complication studies both in vitro and in vivo.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 29741-09-1
• MW: 446.36
• Purity: 99.59% (May vary between batches)
• Formula: C₂₁H₁₈O₁₁
• SMILES: O[C@H]1[C@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
• Target: MMP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.48 mM);DMSO:50 mg/mL (112.02 mM)

Bioactivity

• Target IC50:
  MMP8:22.39 μM|MMP3:12.87 μM|MMP13:0.27 μM|MMP9:17.52 μM
• In Vivo:
  Apigenin-7-O-β-D-glucuronide (AG) suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without affecting cell viability. Additionally, AG suppressed LPS-induced mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α. AG treatment decreased the translocation of c-Jun into the nucleus and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apigenin 7-O-glucuronide, Apigenin7glucuronide, Apigenin-7-glucuronide, Apigenin 7 glucuronide, inhibit, MMP-3, MMP-9, MMP-8, MMP-13, MMP, Matrix metalloproteinases, Inhibitor

Compound Identifiers

PubChem CID

5319484