APcK110

SKU: orb1737807

Description

APcK110 is a novel, potent Kit inhibitor that suppresses proliferation in mastocytosis and AML cell lines by dose-dependently inhibiting Kit phosphorylation and downstream Stat3, Stat5, and Akt signaling. Its superior potency compared to imatinib and dasatinib in models like OCI/AML3 supports its research application in acute myeloid leukemia (AML) therapeutics.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1001083-74-4
• MW: 349.36
• Formula: C₂₀H₁₆FN₃O₂
• SMILES: FC1=CC=C(C=2C=3C(=NC(=CC3)C4=CC(OC)=CC(OC)=C4)NN2)C=C1
• Target: Others,c-Kit

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

24786010