AP23464

SKU: orb1740899

Description

AP23464 is a potent ATP-competitive inhibitor of Src and Abl kinases, including imatinib-resistant Bcr-Abl mutants, with low nanomolar cellular and biochemical activity. It induces cell cycle arrest and apoptosis in Bcr-Abl-expressing cells, making it a valuable research tool for studying CML and kinase resistance mechanisms, though it is ineffective against the T315I mutant.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 845895-51-4
• MW: 475.52
• Purity: 99.79% (May vary between batches)
• Formula: C₂₆H₃₀N₅O₂P
• SMILES: N(C1=C2C(N(CCC3=CC(O)=CC=C3)C=N2)=NC(=N1)C4CCCC4)C5=CC=C(P(C)(C)=O)C=C5
• Target: c-Kit,Others,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

9934643