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AP232 dihydrochloride

SKU: orb3175124

Description

AP232 dihydrochloride is a selective U2AF1-UHM inhibitor with an IC50 value of 7.96 μM. It exhibits 2.8-24 times selectivity over other UHM-containing proteins and demonstrates anti-leukemic activity, showing heightened effectiveness in cell lines with splice factor mutations. AP232 dihydrochloride can induce G2/M and G1 phase arrest in leukemia cells, impair lysosomal acidification, and inhibit autophagy (autophagy). This compound is applicable in cancer research, specifically for leukemia.

Research Area

Cell Biology, Molecular Biology

Images & Validation

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AP232 dihydrochloride

Key Properties

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TargetAutophagy,DNA/RNA Synthesis

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Quick Database Links

Gene Symbol
Autophagy,DNA/RNA Synthesis

Protocol Information

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